Grand Challenge Research Articles

Social work’s grandest challenge: re-contextualizing racism and reducing its deleterious effects on its members and those we serve

ABSTRACT Social work as a profession has a legacy of racism, bigotry, and White supremacy that has harmed a number of racially marginalized groups of people. To this day, social work continues to be beleaguered by racialized activities at the student, practitioner, and research levels that stain its reputation. The author discusses how racist ideologies negatively affect the social work profession and how members of the profession can make immediate changes in social work practice, education, and research in an effort to eliminate racism as one of the grand challenges for social work.

Counter-Doping Effect by Trivalent Cations in tin-based Perovskite Solar Cells.

Sn-based perovskite solar cells normally show low open circuit voltage due to serious carrier recombination in the devices, which can be attributed to the oxidation and the resultant high p-type doping of the perovskite active layers. Considering the grand challenge to completely prohibit the oxidation of Sn-based perovskites, a feasible way to improve the device performance is to counter-dope the oxidized Sn-based perovskites by replacing Sn2+ with trivalent cations in the crystal lattice, which however has been rarely reported. Here, we present the introduction of Sb3+, which can effectively counter-dope the oxidized perovskite layer and improve the carrier lifetime. Meanwhile, Sb3+ can passivate deep-level defects and improve carrier mobility of the perovskite layer, which are all favourable for the photovoltaic performance of the devices. Consequently, the target devices yield a relative enhancement of the power conversion efficiency (PCE) of 31.4% as well as excellent shelf-storage stability. This work provides a novel strategy to improve the performance of Sn-based perovskite solar cells, which can be developed as a universal way to compensate for the oxidation of Sn-based perovskites in optoelectronic devices. This article is protected by copyright. All rights reserved.

Anti-Blackness in Schools of Social Work: A Black Feminist Polyethnography

ABSTRACT Considering the significant contributions of Black women social workers to our profession, and the unyielding stressors and expectations disproportionately affecting Black women in the context of Black Lives Matter and COVID-19, addressing anti-Blackness and understanding the lived experiences of Black women within higher education are essential first steps toward eliminating racism, the 13th and most recently adopted Grand Challenge. Guided by Black feminist polyethnography, this study examined how anti-Blackness is collectively felt and experienced by six Black and mixed Black women faculty and graduate students in schools of social work over their academic careers. Initial steps schools of social work can take to acknowledge and address manifestations of anti-Blackness within existing policies, procedures, curriculum, and dominant school culture are discussed.

Evaporation-induced self-assembled ultrathin AgNW networks for highly conformable wearable electronics

The flexibility and stability of transparent electrodes play a crucial role in the growing popularity of flexible devices, especially in potential wearable electronics. To date, various solution-coating techniques have been developed for fabricating silver nanowire (AgNW) flexible bioelectronics. However, achieving the orderly distributed patterns of AgNW without undesirable aggregations still poses a grand challenge. Here, an approach to realize regular patterned ultrathin AgNW networks on a freestanding electrospun PVDF-TrFE frame by evaporation-induced self-assembly is proposed. The patterning mechanism of evaporating AgNW colloidal suspension is investigated from experimental and theoretical analysis. The influence of evaporation-induced flow inside colloidal freestanding membranes on forming regular square hole-shaped arrays, selective deposition of AgNW, and aligning them along the artificial pinning array are addressed. Owing to the orderly arrangement of AgNW networks, the resultant flexible electrode achieves ultrathin thickness (about 5 μm), high optical transmittance (87.8%), and low sheet resistance (8.4 Ω·sq−1) with a relatively low dosage of AgNW (9 μg·cm−2). The electrode exhibits excellent durability during cyclic bending (50,000 times) and stretching (50% strain). The resistance remains virtually unchanged during 200 days in everyday environments. Furthermore, the excellent conformability and breathability of the flexible transparent electrode attached to the human skin demonstrates its potential application as an e-skin sensor. Our findings reliably urge a simple approach to underscore better outcomes with effective patterns by self-assembly of AgNW for highly conformal wearable electronics.

Fusion plasma turbulence research beyond the burning plasma era: perspectives on transport model validation in fusion and fission

In fusion, the validation of turbulent transport models is undertaken with the goals of making basic physics discoveries as well as for development of new predictive models to improve the operation and enhance the performance of existing and future fusion reactors. A fusion industry is just beginning to emerge globally. Like fission, validation in fusion energy research is a vibrant research area, but unlike fusion, a fission industry exists. The fission power industry motivates validation efforts, often performed at universities with small-scale experiments and advanced models and simulations developed in-house. Because fission research spans basic physics and applications, and addresses near-term and long-term industry interests, validation is thriving. This perspective article describes the validation of turbulent transport models in both fusion research and fission research, draws parallels between the validation methods and techniques used in two areas of the fields, and presents an outlook for thriving university fusion and fission research programs underpinned by a virtual cycle of basic and applied research that supports industry needs as well as tackling intellectual grand challenges.

Grain boundary defect engineering in rutile iridium oxide boosts efficient and stable acidic water oxidation.

PEMWEis considered a promising technology for coupling with renewable energy sources to achieve clean hydrogen production. However, constrained by the sluggish kinetics of the anodic OERand the acidic abominable environment render the grand challenges in developing the active and stable OER electrocatalyst, leading to low efficiency of PEMWE. Herein, we develop the rutile-type IrO2 nanoparticles with abundant grain boundaries and the continuous nanostructure through the joule heating and sacrificial template method. DFT calculations verified that grain boundaries can modulate the electronic structure of Ir sites and optimize the adsorption of oxygen intermediates, resulting in the accelerated kinetics. The 350-IrO2affords a rapid OER process with 20 times higher mass activity (0.61 A mgIr-1) than the commercial IrO2 at 1.50 V vs. RHE. Benefiting from the reduced overpotential and the preservation of the stable rutile structure, 350-IrO2 exhibits the stability of 200 h test at 10 mA cm-2 with only trace decay of 11.8 mV. Moreover, the assembled PEMWE with anode 350-IrO2 catalyst outputs the current density up to 2 A cm-2 with only 1.84 V applied voltage, long-term operation for 100 h without obvious performance degradation at 1 A cm-2.

Interfacial competing interaction eliminates voids in the buried interface for efficient and stable perovskite solar modules on bare NiOX

Perovskite solar cells (PSCs) with impressive efficiency is promising for commercialization. However, when scaling up PSCs to large-area perovskite solar modules (PSMs), the rapid degradation of performance and stability still remains a grand challenge. One of the main causes of the degradation is the presence of local voids in the buried interface for large-area films, which we find could be attributed to the unbalanced interfacial interaction between precursor solvent and substrate. Here we improve a scalable and low-temperature sequential two-step chemical bath deposition process aiming for high quality NiOX. Further with the modulation of A-site cations to enhance the interaction between DMSO and perovskite precursor, the potential for DMSO absorbing on the NiOX could be eliminated. This strategy can inhibit the delay movement of DMSO on NiOX and improve the buried interfacial quality, with compact morphology and absent of voids. The inverted structured PSCs and PSMs based on the bare NiOX and modified perovskite precursor reach a champion efficiency of 22.40% and 19.09%, respectively, which are both among the highest reported values. The highly efficient PSMs also exhibit a long-term operational stability, which retain 84% of the initial performance after 1056 h operating under one-sun illumination.

Surface engineering of biochar toward simultaneously generating superamphiphilicity and catalytic activity for strengthening Pickering interfacial catalysis.

Multifunctional carbon materials have revealed distinctive features and excellent performance in the field of catalysis. However, the facile fabrication of bifunctional carbon materials with special wettability and catalytic activity remains a grand challenge in Pickering emulsion catalysis. Herein, we reported one-step construction of bifunctional biochar with superamphiphilicity and catalytic activity directly from the thermolysis of sawdust and 1-butyl-3-methylimidazolium tetrafluoroborate for enhancing the oxidation of benzyl alcohol in Pickering emulsion. Co-doping of B and F enhanced the hydrophilicity of biochar, and the oleophilicity of biochar was kept simultaneously. Conversion became 4 times using bifunctional biochar compared with blank results during the oxidation of benzyl alcohol. More interestingly, the turnover frequency (TOF) value using bifunctional biochar enhanced 61% than that employing N-doped superamphiphilic carbon without catalytic activity. Catalytic activities of bifunctional biochar could be ascribed to the existence of different chemical bonds containing the element B. This work paves a path toward rational design of bifunctional biochar materials with special wettability and catalytic activity for greatly enhancing the liquid-liquid biphasic reaction efficiencies.

Abstract PS03-07: Morphometric signature identifies ductal carcinoma in situ of the breast with low risk of progression to invasive breast cancer

Abstract Background. Ductal carcinoma in situ (DCIS) is a frequently found precursor of invasive breast cancer (IBC). However, the majority of DCIS will never progress to IBC. As we cannot distinguish yet which DCIS will remain indolent (‘harmless’) from those that might progress in the future to IBC, almost all women with DCIS are intensively treated by surgery, often followed by radiotherapy. This brings an urgent clinical need to learn distinguishing harmless from potentially progressive DCIS to save many women with indolent DCIS the burden of unnecessary overtreatment. Aim. We aimed to investigate if the geometry and spatial configuration of DCIS ducts in Hematoxylin-Eosin (H&E) stained tissue sections are related to the risk of progression of DCIS to ipsilateral IBC (iIBC). Methods. We obtained data from a population-based cohort of women diagnosed with primary DCIS between 1989 and 2004 in the Netherlands, treated with breast conserving surgery (BCS) only and a median follow-up time of 12 years. A nested case-control study (n=689) was designed in which patients diagnosed with iIBC recurrences during follow-up were considered as “cases” (n= 226) and those with no subsequent iIBC as “controls” (n=463). The DCIS and stroma regions were digitally annotated on H&E-stained whole slide images (WSIs) by a pathologist as ground truth for the deep learning neural network of HALO AI module (IndicaLabs). We developed a computational pipeline to automatically detect and measure stroma areas, DCIS ducts, and the nucleus of their cells. We validated the accuracy of DCIS detection in H&Es WSIs from an external study, in which DCIS regions were digitally annotated by an independent pathologist (Translational Breast Cancer Research Consortium, TBCRC). We classified cases and controls according to morphological measurements using logistic ridge regression with double-loop cross-validation, followed by hierarchical clustering. The risk of subsequent iIBC after primary DCIS diagnosis was evaluated by multivariate Cox proportional hazards models. Results. The accuracy of DCIS detection performed by the computational pipeline was compared with pathologist annotations in 20 slides from the TBCRC study. Results showed a satisfactory DCIS overlap area agreement of 0.76 (0.68 – 0.83). We applied the DCIS computational pipeline on the case-control series. We obtained 15 morphological measurements for each DCIS duct, such as duct area, cell density, distance between ducts, average nucleus area, etc. We calculated 8 distribution parameters from each measurement in each WSI, including median and range. After leaving out redundant variables, 55 unique morphometric variables were obtained, representing the heterogeneity of DCIS ducts per WSI. The c lassifier revealed a median area-under the curve (AUC) of 0.66 (0.55-0.77) to predict 5-years free of iIBC, 0.59 (0.50-0.67) to predict 10-years and 0.60 (0.52-0.68) to predict 15-years. The 30 variables with the highest association with outcome were used to build four morphometric signatures. Signature number 1, which is characterized by lesions with small-sized ducts, a lower number of cells and a lower DCIS/stroma area ratio, showed a significant lower risk of developing iIBC compared to the other three signatures in a multivariate Cox regression model including grade, ER, COX-2 and HER2 expression: HR = 0.56 (0.28-0.78 95%CI). Conclusion. We developed a computational pipeline able to detect and measure DCIS ducts in H&E WSIs with high accuracy and reproducibility. DCIS lesions presenting the morphometric signature of small-sized DCIS ducts have a very low chance to progress to invasive breast cancer. After successful validation, our morphometric method will serve as a robust and easy to implement biomarker for de-escalation strategies in DCIS, and as such, could limit unnecessary overtreatment in the near future. Citation Format: Marcelo Sobral-Leite, Simon Castillo, Shiva Vonk, Xenia Melillo, Noomie Lam, Brandi de Bruijn, Yeman Hagos, Joyce Sanders, Mathilde Almekinders, Lindy Visser, Emilie Groen, Carolien Van der Borden, Petra Kristel, Ercan Caner, Leyla Azarang, Yinyin Yuan, Renee Menezes, Esther Lips, Jelle Wesseling, Grand Challenge PRECISION Consortium. Morphometric signature identifies ductal carcinoma in situ of the breast with low risk of progression to invasive breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PS03-07.

A Grand Challenge: Net-Zero Operations—Changing the Definition of “Business as Usual”

_ This is the second of a series of six articles on SPE’s Grand Challenges in Energy, formulated as the output of a 2023 workshop held by the SPE Research and Development Technical Section in Austin, Texas. Described in a JPT article last year, each of the challenges will be discussed separately in this series: geothermal energy; improving recovery from tight/shale resources; net-zero operations; carbon capture, storage, and utilization; digital transformation; and education and advocacy. The first article, “An SPE Grand Challenge Update on Geothermal Energy,” was published in April 2024. _ At COP28, more than 50 oil and gas companies, many of them national companies, took a historic step toward decarbonization by launching the Oil & Gas Decarbonization Charter. The charter represents significant short- and long-term ambitions to reduce emissions, including net-zero operations by 2050 at the latest. This article explores the importance of this effort, the opportunities available to the industry to reduce its Scope 1 and 2 emissions, and the key technologies needed to achieve the net-zero goal. The Size of the Prize According to the latest data from the International Energy Agency (IEA), the production, transport, and processing of oil and gas resulted in 5.1 GtCO2e in 2022. These emissions stem from the production and delivery of oil and gas and the combustion of fossil fuel necessary for operations on-site (Scope 1), and the import of electricity from external sources consumed in oil and gas facilities (Scope 2). These Scope 1 and 2 emissions represent just under 15% of global energy-related greenhouse gas (GHG) emissions. This is a sizable contribution, nearly equivalent to all energy-related GHG emissions from road transport, highlighting the relative scale of the opportunities associated with implementing operational changes in the industry. The faster and deeper these emissions reductions are, the more significant the impact will be. Sources of Emissions To understand the various paths to net zero an oil and gas company can follow, it is critical to map the sector’s sources of emissions throughout the value chain. It is generally recognized that around 60% of an integrated company’s emissions emanate from upstream operations, predominantly from onshore assets. Refining and distribution are the second main contributors, but of a smaller order of magnitude, notably because of significant efforts already made by companies to reduce emissions from their refining assets and levers of decarbonization potentially easier to implement. However, emissions volumes and intensities differ significantly across regions, countries, and asset types. An asset operating in the Canadian oil sands region will have a very different emissions profile compared to an offshore platform in Western African countries. These differing profiles also call for tailored emission-reduction approaches. This means decarbonization studies must be carried out at the asset level, allowing operators to identify the most cost-effective means of tackling emissions reduction.

How to meet Africa's grand challenges with African know-how.

How to meet Africa's grand challenges with African know-how.

Triple-Function Mn Regulation of NiFe (oxy)hydroxide for Oxygen Evolution Reaction

Transition metal (oxy)hydroxides are potential oxygen evolution reaction (OER) electrocatalysts; however, simultaneously modulating multiple factors to enhance their performance is a grand challenge. Here, we report an incorporating heteroatom strategy via one-step hydrothermal approach to adjust more than one factor of Mn-doped NiFe (oxy)hydroxide (Mn-NiFeOOH/LDH) heterojunction. Mn doping regulates heterojunction morphology (reducing nanoparticles and becoming thinner and denser nanosheets), Ni/Fe ratio and valence states (Ni2+, Ni3+, and Ni3+Δ) of Ni ions. The former could effectively increase surface active sites, and the latter two reduce the content of Fe in the Mnx-NiFeOOH/LDH heterojunction, enabling more Ni2+ convert to Ni3+/3+Δ that have higher intrinsic OER activity. As a result, the first-rank Mn-NiFeOOH/LDH with ultra-low overpotential of 185 mV@20 mA cm−2 and 296 mV@500 mA cm−2, and the improved OER performance are outdo to those of commercial RuO2 catalyst for OER. Moreover, the Mn-NiFeOOH/LDH affords the earliest initial potential (1.392 V vs. RHE), corresponds to a recorded low overpotential (162 mV). Based on the density functional theory (DFT), Mn dopants can alter intermediate adsorption energy and effectively decrease OOH*’s energy barrier. This research exhibits a feasible strategy to design low cost electrocatalysts and provide new possibilities for future industrialization.

Current Perspectives on Attention-deficit Hyperactivity Disorder.

Attention-deficit hyperactivity disorder (ADHD) is a neurobiological and neurodevelopmental disorder with an idiosyncratic genetic base. ADHD presents various characteristics, such as inattention, hyperactivity, and impulsivity. Over the period, ADHD leads to noticeable functional disability. A five- to ten-fold progressed risk of disorder development is observed in the populations with familial history of ADHD. The abnormal structure of the brain in ADHD results in altered neural mechanisms, such as cognition, attention, and memorial function. The mesolimbic, nigrostriatal, and mesocortical pathways in the brain get affected by the deterioration of the levels of dopamine. The hypothesis of dopamine in ADHD and its etiopathology suggests that detained attention and impaired arousal functions are due to reduced levels of dopamine. The quickest way to improve strategical treatment is by clarifying the etiological aspects of ADHD and identifying the underlying mechanisms of pathophysiology, which will assist in exploring the biomarkers for better diagnosis. The implementation of life course theory is a very important research principle announced by Grand Challenges in Global Health Initiative (GCMHI). Long-term research is needed to define the progression of ADHD. Interdisciplinary collaborations promise a great future for research innovations in ADHD.

On the conditions for self-catapulting of freezing water droplets

Despite the remarkable progress of anti-icing and deicing technologies in the past decades, it remains a grand challenge to dislodge freezing water from a solid surface without consuming external energy. Herein, we propose a strategy to dislodge freezing water from solid surfaces just by leveraging its volume expansion resulting from the phase change from water to ice. The implementation of this energy-saving strategy relies on a simple micropillar-based gadget on the surface, termed freezing-empowered droplet catapult (FEDC), whereby the work done by the volume expansion of a freezing droplet accreted on it can be harvested and stored as elastic energy, and subsequently released in due course to catapult the freezing droplet away from the surface. Mechanics-based modelling is carried out to reveal the necessary conditions of occurrence for the self-catapulting of freezing water droplets on an FEDC, yielding a phase map that manifests the necessary synergy among the characteristic dimensions and stiffness of the FEDC as well as the volume of the droplet in triggering its self-catapulting. Our study not only demonstrates the feasibility of an energy-saving strategy for shedding off freezing droplets from solid surfaces but also provides a quantitive guideline for the design of the gadget for implementation, paving the way to a new technology for controlling ice accretion on solid surfaces with zero consumption of external energy.

A Self-Transformed N-chlorinated ε-Polylysine coating endows titanium implants with programmed integration of robust antibacterial and Pro-Osteogenic abilities

Implant-associated infection and poor osseointegration are the main causes of orthopedic implantation failure. For a long-term successful implantation, simultaneously introducing prevention of infection and promotion of osteogenesis into implants is highly desired but remains a grand challenge. Inspired by the human immune mechanism of tissue repair under bacterial infection, we propose a self-transformed strategy for the modification of titanium with porous N-chlorinated ε-polylysine coating (Ti-PL-NCl) through pore-making, surface grafting and chlorination. The as-prepared Ti-PL-NCl exhibits an excellent antibacterial activity against S. aureus and E. coli in the presence of N-chloramine in the early stage, with an antibacterial rate as high as 95.8% and 99.4%, respectively. With the consumption of oxidative chlorine, the N─Cl groups of Ti-PL-NCl are transformed into N─H groups with moderate antibacterial yet strong pro-osteogenic abilities. The self-transformed N-chlorinated ε-polylysine coating enables Ti-PL-NCl to achieve long-lasting antibacterial activity as well as enhanced pro-osteogenesis, thus providing adaptive bioactivities for bone-implant integration. Rat implant-associated osteomyelitis model confirms that Ti-PL-NCl has excellent efficacy of infection prevention and osseointegration promotion. This work may provide a new paradigm of designing multifunctional implants to achieve long-term successful implantation.

Noncovalent synthesis of homo and hetero-architectures of supramolecular polymers via secondary nucleation

The synthesis of supramolecular polymers with controlled architecture is a grand challenge in supramolecular chemistry. Although living supramolecular polymerization via primary nucleation has been extensively studied for controlling the supramolecular polymerization of small molecules, the resulting supramolecular polymers have typically exhibited one-dimensional morphology. In this report, we present the synthesis of intriguing supramolecular polymer architectures through a secondary nucleation event, a mechanism well-established in protein aggregation and the crystallization of small molecules. To achieve this, we choose perylene diimide with 2-ethylhexyl chains at the imide position as they are capable of forming dormant monomers in solution. Activating these dormant monomers via mechanical stimuli and hetero-seeding using propoxyethyl perylene diimide seeds, secondary nucleation event takes over, leading to the formation of three-dimensional spherical spherulites and scarf-like supramolecular polymer heterostructures, respectively. Therefore, the results presented in this study propose a simple molecular design for synthesizing well-defined supramolecular polymer architectures via secondary nucleation.

Grand Challenges Viewed through the Pragmatist Lens of the Economies of Worth: A Multidisciplinary Review and Framework for the Conduct of Moral Work in Pluralistic Settings

Grand Challenges Viewed through the Pragmatist Lens of the Economies of Worth: A Multidisciplinary Review and Framework for the Conduct of Moral Work in Pluralistic Settings

Impact of Soil Moisture Dynamics and Precipitation Pattern on UK Urban Pluvial Flood Hazards Under Climate Change

AbstractThe diversity of flood‐generating mechanisms superimposed on catchment physiographic features with non‐stationary meteorological drivers makes future flood hazard assessment a grand challenge. To date, many studies have examined patterns in rainfall and streamflow, but far fewer have investigated trends in the other drivers of flooding. The complex transfer function between precipitation and flooding makes it potentially misleading to simply look at the change in rainfall to express the hazard. Furthermore, there are very few studies that have directly used output from km‐scale climate models in flood modeling. Coarse resolution climate data sets may not credibly resolve local climate and weather extremes. Changes in rainfall distribution and antecedent moisture over extended time periods due to climate change have so far been ignored when assessing urban pluvial flood risk. In this paper, an urban flood hazard assessment framework using the latest 2.2 km resolution UK Climate Projections Local is proposed. Global warming induced changes in pluvial flood risks under RCP8.5 are projected, focusing on the impact of changing precipitation patterns and soil moisture dynamics on flood generation. Results indicate a strong increase in the frequency of occurrence of extreme floods, and the resultant future (2060–2080) annual flood volume is expected to increase up to 52.6% relative to 1980–2000 over a major UK urban region, and these patterns are likely to hold more generally elsewhere in the UK. Shifts to a later occurrence of extreme flooding is identified under global warming. Previous studies that have neglected soil moisture dynamics are unlikely to give accurate flood estimates.

Innovative large-scale open-jet testing to address grand challenges in resilient and sustainable built environments

Innovative large-scale open-jet testing to address grand challenges in resilient and sustainable built environments

A Versatile Strategy for the Controlled Synthesis of Atomically Precise Palladium Nanoclusters.

The study of the structures, applications, and structure-property relationships of atomically precise metal nanoclusters relies heavily on their controlled synthesis. Although great progress has been made in the controlled synthesis of Group 11 (Cu, Ag, Au) metal nanoclusters, the preparation of Pd nanoclusters remains a grand challenge. Herein, a new, simple, and versatile synthetic strategy for the controlled synthesis of Pd nanoclusters is reported with tailorable structures and functions. The synthesis strategy involves the controllable transformations of Pd4(CO)4(CH3COO)4 in air, allowing the discovery of a family of Pd nanoclusters with well-defined structure and high yield. For example, by treating the Pd4(CO)4(CH3COO)4 with 2,2-dipyridine ligands, two clusters of Pd4 and Pd10 whose metal framework describes the growth of vertex-sharing tetrahedra have been selectively isolated. Interestingly, chiral Pd4 nanoclusters can be gained by virtue of customized chiral pyridine-imine ligands, thus representing a pioneering example to shed light on the hierarchical chiral nanostructures of Pd. This synthetic methodology also tolerates a wide variety of ligands and affords phosphine-ligated Pd nanoclusters in a simple way. It is believed that the successful exploration of the synthetic strategy would simulate the research enthusiasm on both the synthesis and application of atomically precise Pd nanoclusters.